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 Glucophage is a trade name for the oral anti-hyperglycemic agent metformin HCL. It is generally used in the management of mature onset (Type-Il) diabetes and utilized when dietary management and exercise alone have not been able to control the disease, yet injectable insulin is not appropriate since this hormone is still present in the body. While the main activity of Glucophage (metformin HCL) is the increased utilization of glucose, it does not directly mimic the action of insulin. The precise mode of action is actually unknown, but it is believed to increase insulin sensitivity through some peripheral process. Use of Glucophage (metformin HCL) will certainly lower the patient's blood sugar, but its activity makes it unlikely to cause a state of hypoglycemia if the dosage of Glucophage is accidentally misjudged (a major concern with injectable insulin).
The concept of harnessing insulin for performance enhancement has been catching on in recent years. As you may know, insulin is considered a "storage hormone". Injectable insulin can be extremely risky however, an incorrect dosage or insufficient carbohydrate intake having grave consequences to the user's health. In extreme cases, hypoglycemia (low blood sugar) can lead to coma or even death. Since this effect is rare with Glucophage, it is considered by many athletes to be an introduction to insulin manipulation.
When administered, the absorption rate of Glucophage (metformin HCL) is very slow. Metformin HCL will make its way to circulation slowly, over a period of about six hours. The general intake schedule among bodybuilders is to take 850mg (one tablet) twice per day. The user will be sure to additionally supplement with a carbohydrate replacement (such as Ultra Fuel) and with creatine monohydrate, particularly after periods of training. The result of Glucophage's treatment will probably not be as dramatic as when using insulin, but a notable anabolic effect can be achieved nonetheless. Most athletes opt to use this drug for a limited duration, cycles of Glucophage usually lasting only a couple of months. This would be followed by an equally long break (at a minimum).
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